Active substances: Orlistat
African-American subjects reported missing 19. Reasons given for noncompliance with the thrice-daily orlistat regimen were: having skipped a meal e.
Fecal fat excretion increased from 5. Reports of the adverse effects experienced, obtained weekly for the first 3 months of the study period, found the gastrointestinal effects of orlistat were generally mild and transient.
A detailed description of the adverse effects was previously reported 29. There were no significant changes in the serum levels of the fat-soluble vitamins A, E after correcting tocopherol levels for the change in lipid concentrations, or K.
A small, but significant, decrease in 25-hydroxy vitamin D levels was seen at 1 month 14. Serum iron levels rose slightly for the group as a whole from 52. There were no significant changes observed in ionized calcium, phosphorous, magnesium, zinc, intact PTH, osteocalcin, bone-specific alkaline phosphatase, TSH, free T 4, apolipoproteins A 1 and B, or triglycerides during the study.
In addition, the gallbladder and renal ultrasound studies found no abnormalities, either at baseline or at follow-up visits.
Waist circumference decreased from 112. Fasting serum leptin, 30. When the data were separated according to race Table 2, at baseline, African American subjects were significantly more obese than Caucasian subjects BMI 50.
There was also a uniform and significant difference in response to the intervention between African American and Caucasian subjects. When one African American subject who gained 11.
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