Active substances: Orlistat
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Researchers looked at 29 clinical trials including 1497 patients in pain. Sneezy to acclimatise I'm in your head, Wes. Two large placebo-controlled trials evaluated the effect of orlistat in a dosage of 120 mg three times daily or placebo in addition to a low-calorie diet for one year, followed by a second year of active drug or placebo and a weight-maintenance diet.
Results of both studies showed that after one year, patients taking orlistat lost an average of 9 to 10 kg 19. In the second year, patients who continued to take orlistat regained 1.
Those taking orlistat showed significant but clinically trivial improvements in cardiovascular risk factors compared with those taking placebo.
After one year, diastolic blood pressure in the orlistat group decreased by an average of 2 mm Hg; after two years, total cholesterol levels in this group decreased by 5 mg per dL 0.
In a double-blind trial using orlistat for weight maintenance in 729 patients who had lost about 10 kg 22 lb by diet alone, patients taking 120 mg of orlistat three times daily for one year regained a mean weight of 2.
Results indicated that about 24 percent of patients taking orlistat did not regain weight compared with 16 percent of those who were placebo-treated.
Obese patients with type 2 diabetes formerly called non—insulin-dependent diabetes mellitus who were treated with orlistat in a dosage of 120 mg three times daily in addition to diet for one year lost a mean weight of 1.
No study data are available comparing the use of orlistat with phentermine or sibutramine, the only drugs that are labeled by the U. A total of 20 to 40 percent of patients taking orlistat exhibited symptoms such as flatulence with discharge, oily spotting and fecal urgency.