Active substances: Norfloxacin
The overall rate of adverse events in patients treated with fluoroquinolones is roughly similar to that seen in patients treated with other antibiotic classes.
Centers for Disease Control study found patients treated with fluoroquinolones experienced adverse events severe enough to lead to an emergency department visit more frequently than those treated with cephalosporins or macrolides, but less frequently than those treated with penicillins, clindamycin, sulfonamides, or vancomycin.
Among these, tendon problems and exacerbation of the symptoms of the neurological disorder myasthenia gravis are the subject of "black box" warnings in the United States.
Younger people typically experience good recovery, but permanent disability is possible, and is more likely in older patients. Simultaneous use of corticosteroids is present in almost one-third of quinolone-associated tendon rupture.
Fluoroquinoline treatment is associated with risk that is similar to or less than that associated with broad spectrum cephalosporins. Therefore, cyclosporine serum levels should be monitored and appropriate cyclosporine dosage adjustments made when these drugs are used concomitantly.
Medications Some quinolones exert an inhibitory effect on the cytochrome P-450 system, thereby reducing theophylline clearance and increasing theophylline blood levels. Hepatic abscess Klebsiella liver abscess ref.
Klebsiella sp. For echinococcus, see Table 13, page 160.
In pyogenic abscess, V? If amoeba serology positive, treat with metro alone without surgery. Empiric metro included for both E. For both compounds, 24 h urinary creatinine clearance was supported as a descriptor of drug clearance.Blood samples were analysed using a were performed using non-linear mixed-effects modelling. Population pharmacokinetic analysis and dosing simulations validated ultra HPLC-tandem mass spectrometry technique.