Active substances: Gabapentin
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Abstract Objective: Gabapentin is commonly used off-label in the treatment of psychiatric disorders with success, failure, and controversy.
A systematic review of the literature was performed to elucidate the evidence for clinical benefit of gabapentin in psychiatric disorders. Study selection and data extraction: The resulting 988 abstracts were read by 2 reviewers; references were excluded if gabapentin was not a study compound or psychiatric symptoms were not studied.
The resulting references were subsequently read, reviewed, and analyzed; 219 pertinent to gabapentin use in psychiatric disorders were retained.
Only 34 clinical trials investigating psychiatric disorders contained quality of evidence level II-2 or higher.