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    Correspondence and reprints requests to: Charles L. Loprinzi. Abstract Background Hot flashes are a complication of androgen deprivation therapy given to men with prostate cancer.

    The purpose of this current study was to examine the efficacy and toxicity of gabapentin over a longer term. Methods In this open-label continuation phase study, men in a previous phase III trial of gabapentin for hot flashes, were studied.

    They were to complete a hot flash diary daily and keep weekly logs of toxicity, satisfaction with hot flash control, and effect on QoL, for eight additional weeks.

    Results The moderate reduction in hot flash frequency and severity appeared to be maintained during the continuation phase.

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    Using a scale from 1 to 4, patients recorded the daily number of mild, moderate, severe, and very severe hot flashes. The highest dose used in the study was less than one-third of the dose that can be used to treat epileptic seizures, Dr.

    Loprinzi says, leaving room for possible improvements in effect against hot flashes with an increase in dosage. Similarly, a sudden loss of testosterone in men, from androgen deprivation therapy, can also result in hot flashes.

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    Testosterone is part of a class of compounds known as androgens, which are largely steroid hormones.

    More What is Neurontin? Neurontin gabapentin is an anti-epileptic drug, also called an anticonvulsant.

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