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To minimize patient test burden, we used the nine-item word list test in lieu of the word naming in the TICS test during the preoperative testing.
Results are not included in this article. Secondary outcomes included postoperative pain, opioid use, and the length of hospital stay.
Training of the research assistants in the use of the CAM was described in our previous publication. Postoperative intravenous opioid use was measured for the first 3 postoperative days.
Postoperative length of stay was measured and compared between interventional and control groups.The primary outcome was postoperative delirium as measured by the Confusion Assessment. Top Abstract Background: Postoperative pain and opioid use are associated with postoperative.
Subgroup Analyses For subgroup analysis, which was preplanned, we stratified patients by preoperative risk status: low risk was defined as patients with risk scores of three or less and high risk with risk score of more than 3 based on our previous risk prediction index where one point was assigned each to female sex, history of central nervous system disorder, high surgical risk, and age greater than 75 yr.
Briefly, surgical risk was estimated by taking into consideration the type and duration of surgery and intraoperative blood loss.
For the secondary outcomes, subjectively reported pain scores by the visual analog scale were stratified into low 1 to 3, medium 4 to 6, or high 7 to 10 for each postoperative day.
The difference in pain levels was measured by chi-square between gabapentin and placebo groups. Opioid use was defined as low versus high.
Cutoff value for opioid dose use was based on the top third quartile 75 th percentile on 3 postoperative days, respectively. The justification of stratifying opioids dose into high- versus low-dose for analysis was based on our previous work on a model of prediction of postoperative delirium.
Hospital lengths of stay between groups were compared using the unpaired t test.