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Conclusion It is known from in-vitro studies that PDE-6, which is found predominantly in retinal photoreceptors, is a key enzyme in the phototransduction cascade. For this reason, retinal effects of PDE inhibitors are not unexpected. PDE-6 is also weakly inhibited by PDE-5 inhibitors and high plasma concentrations of the latter can be expected to inhibit the phototransduction process in retinal photoreceptors.