Active substances: Doxycycline
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Probing pocket depth, clinical attachment level, gingival index, plaque index, and bleeding on probing were collected at baseline, 45 days after SRP, and one, and 6 months after the use of systemic doxycycline.
Microbiological analysis comprised the detection of Tannerella forsythia Tf, Aggregatibacter actinomycetemcomitans Aa, Porphyromonas gingivalis Pg, and Prevotella intermedia Pi by polymerase chain reaction method. The relationship between periodontal diseases PD and diabetes are bidirectional, 1 which provides an example of systemic disease predisposing to oral infection, established infection, and exacerbating the systemic disease.
Diabetics exhibit greater severity and a faster rate of PD progression.
Treatment of PD is directed to the elimination of sub-gingival bacterial infections. More than 700 different bacterial species are found in the sub-gingival environment.
Subgingival scaling and root planning SRP is an effective method to slow or arrest the progression of PD. The benefits of using various adjunctive antibiotics such as penicillin, tetracycline, amoxicillin, and metronidazole along with SRP have been reported to improve periodontal health.
A total of 76 diabetic subjects with chronic periodontitis were included in this study. This study was conducted in accordance with the Helsinki Declaration of 1975, as revised in, and the protocol of this study was approved by the research ethics committee of Sultan Bin Abdulaziz Humanitarian City, Riyadh, Saudi Arabia.
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