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Search Menu Abstract Background. Recent studies have raised concern about efficacy of azithromycin for Chlamydia trachomatis infection.
Men and nonpregnant women aged 19—45 years with a urogenital chlamydial diagnosis or a sexual partner with chlamydia were eligible. The primary outcome was microbial cure by nucleic acid amplification testing at day 28.
A total of 495 subjects were randomized. The modified intent-to-treat mITT population with evaluable efficacy consisted of 323 subjects. Baseline patient characteristics did not differ between the mITT groups.
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Based on GISP data, CDC recommends combination therapy with ceftriaxone 250 mg intramuscularly and either azithromycin 1 g orally as a single dose or doxycycline 100 mg orally twice daily for 7 days as the most reliably effective treatment for uncomplicated gonorrhea.
CDC no longer recommends cefixime at any dose as a first-line regimen for treatment of gonococcal infections.
If cefixime is used as an alternative agent, then the patient should return in 1 week for a test-of-cure at the site of infection.
Infection with N. Gonorrhea treatment has been complicated by the ability of N. During the 1990 s and s, fluoroquinolone resistance in N.
In, emergence of fluoroquinolone-resistant N. To ensure treatment of co-occurring pathogens e. From to, the minimum concentrations of cefixime needed to inhibit the growth in vitro of N.
Reports from Europe recently have described patients with uncomplicated gonorrhea infection not cured by treatment with cefixime 400 mg orally 5—8.