Active substances: Doxycycline
Doxylin What is doxycycline? IHCs are the primary sensory cells of the auditory system, whereas the OHCs are eletromechanical amplifiers that improve hearing sensitivity by more than 40 dB. A previous study showed that the ABR threshold to pure tone sounds was increased by 40 dB when the OHCs but not the IHCs in parts of the cochlea were destroyed by kanamycin treatment.
It works by preventing bacteria from reproducing through the inhibition of protein synthesis.
It can also be re-absorbed in the renal tubules and gastrointestinal tract due to its high lipophillicity so has a long elimination half life, and does not accumulate in the kidneys of patients with kidney failure due to the compensatory excretion in faeces.
It inhibits the synthesis of bacterial proteins by binding to the 30 S ribosomal subunit, which is only found in bacteria.
This stops bacterial growth giving the immune system time to kill and remove the bacteria.
There are also some common medicines you should not mix with it.
Doxycycline can also be called by the brand name Vibramycin-D. Who can and can't take doxycycline Doxycycline can be taken by adults and children over 12 years old.
Doxycycline is not usually recommended in pregnancy or when breastfeeding. It isn't suitable for some people. To make sure this medicine is safe for you, tell your doctor if you have: ever had an allergic reaction to doxycycline or any other medicine in the past kidney problems an inflamed food pipe oesophagitis lupus, an autoimmune disease myasthenia gravis, an illness that causes severe muscle wasting 4.
How and when to take it Your dose of doxycycline depends on why you are taking it. The usual dose is 100 mg to 200 mg once or twice a day. If you're taking doxycycline more than once a day, try to space your doses evenly throughout the day.
If you take it twice a day, this could be first thing in the morning, and in the evening. For preventing malaria, you'll take 100 mg once a day, usually in the morning. If you forget to take your dose, take it as soon as you remember.
It is important to take the whole course of antibiotics for the number of days your doctor has told you to. Do not stop taking it, even if you feel your infection has cleared up. Talk to your doctor first.
Taking other medicines Taking some medicines such as antacids and iron preparations at the same time as doxcycline can reduce its effect in fighting infection.
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