Active substances: Doxycycline
These patients had symptoms of burning and tingling associated with a sunburn-like eruption which lasted an average of 10 to 14 days.
Photosensitivity was not correlated with sex, age, use of topical adjuvant therapy, or duration of doxycycline therapy.
A particular strength of our study is that we had data on a large number of patients with the same clinical entity who were treated at a single medical centre and given the same instructions, thus avoiding potential confounders when comparing data from different centres not using uniform approaches.
The frequency of doxycycline-induced photosensitivity found in our study is at the lower limit of some earlier reports. However, some other studies with lower daily dosages and shorter treatment duration found similarly high incidence rates of doxycycline-induced photosensitivity.
Another possible explanation for the differences encountered could be variations in exposure to the sun. However, since we obtained data on sun exposure only in patients who reported photosensitivity but not in those who did not experience this adverse event, we could not evaluate the magnitude of the impact of sun exposure for development of photosensitivity.
This is a major limitation of our study.
The second limitation of our study is the fact that exact timing of the onset of photosensitivity reactions for the majority of patients experiencing photosensitivity was not obtained. This accords with earlier findings that doxycycline-induced photosensitivity might depend on the dose of doxycycline and the intensity of UV-A radiation, but is not related to duration of therapy.
ETR can resemble seborrhoeic dermatitis, which, in fact, can co-exist with rosacea seborosacea.
Periorofacial dermatitis Periorofacial dermatitis usually presents with inflammatory papules around the mouth, eyes and nasal area.
This is often caused by the prolonged use of potent topical corticosteroids on facial skin. Some acne lesions also cause scarring.
It is characterised by a fixed blush appearance, especially on the lateral cheeks, with fine follicular keratotic plugs.