Active substances: Doxycycline
The lifespan reached 332.
Recently, our preliminary results of in vitro and in vivo studies on zinc oxide compositions of antibiotic drug-doxycycline have been obtained and it was demonstrated to increase antibacterial activity by a factor of 2 in comparison with the initial drug.
At present, the main problems of modern antibacterial therapy are increasing the efficiency, reducing the toxicity of treatment and decreasing resistance of bacterial infections to drugs.
At present, actual tasks are the methods development for modification of known antibacterial substances.
It was shown that doxycycline zinc oxide compositions in the form of composite films with polyvinyl alcohol PVA reveal activity at lower concentration by a factor of 2 in comparison with the pharmaceutical preparation and doxycycline-PVA composite film.
In vivo study of doxycycline zinc oxide compositions on the model of white mice generalized staphylococcal and dysenteric infections using St. Much the same difference was observed for Sh Flexneri 6858 strain.
It is a zoonotic parasitic disease mainly located in temperate, tropical, and subtropical areas of the world Different species of culicid mosquitoes belonging to the genera Culex, Aedes, and Anopheles, among others, have been implicated in the transmission of this parasite, allowing for its intermediate stage to complete its life cycle.
Heartworm infection is a severe and life-threatening disease.
The pathophysiological response to heartworm infection is mainly due to the presence of adult worms of Dirofilaria immitis in the pulmonary arteries and right ventricle of the heart.
The worm numbers, host immune response, duration of infection, and host exercise levels determine the severity of the cardiopulmonary pathology. Clinical manifestations include cough, dyspnea, weight loss, poor exercise tolerance, weakness, hemoptysis, cyanosis, and congestive heart failure.
Canine heartworm infection is preventable and chemoprophylaxis is a priority in heartworm endemic areas.
One of the goals of prevention is to reduce the reservoir population and decrease the prevalence of infection among unprotected dogs. Prevention should start before the mosquito season in spring and should be continued until late fall.
The treatment of heartworm infection is neither simple nor safe in itself. The American Heartworm Society recommends the melarsomine dihydrochloride three-injection protocol 2.
The presence of Dirofilaria immitis in dogs supposes a risk for the human population. Epidemiological, molecular, and immunological studies as well as clinical practice have discovered an increasing number of countries in which clinical cases of human dirofilariasis are reported, while seroepidemiological studies suggest that humans frequently become infected with Dirofilaria spp.
This information has changed the picture of human dirofilariasis from a sporadic to an emerging disease.
In Portugal, a case of human ocular dirofilariasis was reported, and two cases of D. In the human host, Dirofilaria immitis is the causative agent of pulmonary dirofilariasis, and in many cases produces benign pulmonary nodules usually identified incidentally by chest radiography in asymptomatic patients, which can initially be misidentified as malignant tumors.