Active substances: Doxycycline
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Doxycycline is most effective when given within the first 5 days of illness. Because there is no rapid test to diagnose rickettsial diseases, clinicians must diagnose and treat based on clinical suspicion alone.
It is important that concern about dental staining not cause providers to use other antibiotics, or delay the start of treatment in children.
A step-wise approach to laboratory testing is recommended. The first step is screening by an enzyme immunoassay or immunofluorescent antibody assay.
Although it is known that doxycyline is a blood schizontocide, 45 the exact mechanism of action is not well defined.
On the basis of these studies, the recommended duration of the post-exposure course of doxycycline is 4 weeks. Doxycycline has no effect on the hypnozoites of the Plasmodium species.
Only one study was found that looked at gametocytemia and doxycycline.