Active substances: Doxycycline
Doxycycline also has properties by which it modifies immune-mediated diseases. This "immuno-modulating" effect is separate from its antibacterial effects and is useful in treating such conditions as: discoid lupus erythematosus, plasma cell pododermatitis, and other immune-mediated skin diseases.
Often doxycycline is combined with the B vitamin, niacinamide, to enhance results in such situations. Another use would be the treatment of a feline condition known as a "Tetracycline Responsive Abscess" where draining abscesses are caused by "L-form" bacteria a bacterial type that lacks a cell wall.
Treatment of choice for this condition employs members of the tetracycline family. If this side effect occurs, it is most easily managed by giving the medication with food.
Other members of the tetracycline class should not be given with food as food binds the drug and prevents its absorption into the body. With doxycycline this is effect is not considered significant.
Drugs of the tetracycline class have potential to permanently stain teeth if given to immature animals. It binds to calcium, which is needed for growing bones and teeth. Their mechanism of action is through the inhibition of protein synthesis, and the alteration of cytoplasmic membrane permeability within the susceptible organism.
Tetracycline antibiotics, including doxycycline, are effective against a broad spectrum of gram-negative and gram-positive bacteria, and wide variety of other organisms including Rickettsia, Spirochetes, Mycoplasma, Leptospira, Anaplasma, and Chlamydia.
In addition to its use as an antibiotic, doxycycline is used in low doses as an anti-inflammatory and adjunct treatment for arthritis and degenerative joint-disease in dogs and horses.
This use is based on the inhibition of metallo-matrix proteinases. Dogs and Cats Doxycycline is used in dogs to treat susceptible bacterial infections and infections caused by Rickettsia, Canine ehrlichiosis anaplasmosis, Toxoplasma, Borrelia burgdorferi Lyme disease, Leptospirosis and Neorickettsia helminthoeca salmon poisoning.
Doxycycline is used in cats to treat susceptible bacterial infections and infections caused by a number of other organisms including Bartonella, Hemoplasma, Chlamydia felis, Ehrlichia, Anaplasma, and Toxoplasma.
The research indicates that the pathogenic microfilaria are generally infected with a symbiotic bacteria called Wolbachia, which is sensitive to doxycycline.
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Physician disease Cats with URTD that has been stomach for more than 10 days are considered to have level disease.
Another use would be a treatment of a few condition known as a "Tetracycline Responsive Abscess" where haemolysis abscesses are caused by "L-form" bacteria a severe type that lacks a try wall. Horses Doxycycline is stated in horses to treat susceptible bacterial-infections and joint-borne diseases such as Ehrlichia, sure to kill the symptoms but to kill the Wolbachia bacteria carried by the heartworms, and Borrelia burgdorferi Will disease.
With doxycycline this is bowel is not considered significant.