Active substances: Clomiphene
Further information: Ovulation induction Clomifene is one of several alternatives for ovulation induction in those who are infertile due to anovulation or oligoovulation.
Serial transvaginal ultrasound can reveal the size and number of developing follicles.
Clomiphene citrate with tamoxifen versus tamoxifen alone Clinical pregnancy rate There was insufficient evidence to determine whether there was a difference between groups OR 3.
No data were reported for the other outcomes.
Other comparisons of interest Limited evidence suggested that compared with a gonadotropin, clomiphene citrate was associated with a reduced chance of a pregnancy, ongoing pregnancy, or live birth, with no clear evidence of a difference in multiple pregnancy rates.
The comparison of clomiphene citrate plus medical adjunct versus clomiphene alone was limited by the number of trials reporting the comparison and poor reporting of clinical outcomes relevant to this systematic review and by the number of adjuncts reported ketoconazole, bromocriptine, dexamethasone, combined oral contraceptive, human chorionic gonadotropin, hormone supplementation.
The addition of dexamethasone or combined oral contraceptive suggested a possible benefit in pregnancy outcomes, but findings were very uncertain and further research is required to confirm this.
Data for early versus late regimens of clomiphene citrate were insufficient to be able to make a judgement on differences for pregnancy outcomes.
Due to low event rates, we advise caution interpreting these data. The comparison of clomiphene citrate plus medical adjunctive versus clomiphene alone was limited by the number of trials reporting the comparison.
The evidence was very low quality and no firm conclusions could be drawn, but very limited evidence suggested a benefit from adjunctive dexamethasone or combined oral contraceptives.
Background Subfertility due to the absence of ovulation is a common problem in women.
Thus, Clomid is not an infertility treatment cure-all. Clomid does not increase your chances of pregnancy if you have infertility factors that are unrelated to ovulation, such as blocked tubes, uterine abnormalities, ovarian failure, pelvic lesions, certain male infertility factors, etc.
The side effects are usually very mild One of the reasons doctors and their patients prefer Clomid is that it has reasonable success rates and minimal low-risk side effects. Those who do have side effects report bloating, nausea or headaches.
This would normally be produced by the embryo in the effort of maintaining progesterone and estrogen levels during pregnancy.Clomid is a prescription drug that should only be taken under the guidance of a medical professional.