Active substances: Clomiphene
Genotoxicity of CC has been poorly investigated in eukaryotic systems and in some bacterial systems. Ohnishi et al. Arriaga-Alba et al.
London et al. In vitro.
Further genotoxicity studies should be conducted especially for raloxifene. Keywords: Genotoxicity, Clomiphene, Tamoxifen, Toremifene, Raloxifene, Review Introduction Estrogens are a class of sex steroid hormones that are synthesized from cholesterol and are secreted primarily by the ovaries, with contributions from placenta, adipose tissue, and adrenal glands Lewis and Craig Jordan.
They have a number of important physiological effects on hormone-dependent reproductive tissues Robertson. They control the growth of breast epithelial tissue, regulate the menstrual cycle by promoting endometrial proliferation in the uterus, and regulate circulating cholesterol levels, thereby providing a protective effect on the cardiovascular system Robertson; Jordan 1996.
The biological role of estrogen is mediated through high-affinity binding to the estrogen receptor ER Robertson; Cavailles. Exposure to high level of estrogens, especially due to in vitro fertilization, can cause different tumours.
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