Active substances: Ciprofloxacin
Damage to the central nervous system CNS from GPS is quite rare in the absence of anti-neutrophil cytoplasmic antibodies ANCA, and has only been described in 4 cases in the medical literature.
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She also received intravenous immunoglobulin as outlined in previous cases. There were no complications related to the PP, and renal function partially improved with creatinine at discharge of 2.
His creatinine at discharge was 2. A renal biopsy showed borderline changes with positive C 4 d staining, and no observable donor-specific antibodies.
The immunosuppressive treatment was changed to tacrolimus, and he was given 3 boluses of methylprednisolone and underwent 5 PP sessions with total volume SSPP replacement.
He also received intravenous immunoglobulin after the PP sessions.
There were no complications, and partial improvement was observed with a decrease in creatinine to 2. A 28-year old man with an underlying disease of the heat shock factor family. Follow-up revealed poor compliance.
A renal biopsy showed IA acute cellular rejection with positive C 4 d staining and anti-class II donor-specific antibodies.
He received boluses of methylprednisolone 500 mg in 3 doses and 6 PP sessions with total volume SSPP replacement, as well as immunoglobulins. He had some non-specific, post-PP itchy reaction which was resolved with antihistamines.
Renal response was partial, with a decrease in creatinine to 4.