Active substances: Ciprofloxacin
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Otic drops provide an advantage over systemic antibiotic drug therapy by providing a higher concentration of medication at the infection site and avoiding the adverse effects of systemic treatment. Otic drops that contain aminoglycosides have been shown to be ototoxic in animal studies and case reports.
Fluoroquinolone-containing otic preparations currently indicated for use in the middle ear space include ofloxacin. The safety of ototopical ciprofloxacin has been shown after standard treatment.
In vitro studies 15, 16 of ciprofloxacin have been performed on chinchilla outer hair cells. Chinchilla outer hair cells were isolated and exposed to various ototopical medications, including neomycin.
All of the evaluated substances resulted in outer hair cell death, thereby demonstrating the potential for ototoxicity. The goal of this study is to determine whether use of a fluoroquinolone topical otic suspension ciprofloxacin.
Owing to the demonstrated potential for ototoxicity of fluoroquinolones as evidenced in the chinchilla model, we hypothesized that prolonged exposure of the middle ear to ciprofloxacin produces measurable ototoxicity as measured using the auditory brainstem response ABR threshold.
The cyst is the infectious form and is ingested in contaminated water or food or directly from fecal-oral contact.
After ingestion, excystation occurs. Excystation is thought to be initiated by contact with acidic gastric contents, followed by a highly coordinated sequence of events leading to the release of one or two trophozoites 27, 109, 210.
The trophozoite infects the duodenum and upper intestine, which have a favorable alkaline pH, and gives rise to the clinical sequelae.
JM does not report any allergies to medications and is currently only taking a daily multivitamin and a combined hormonal oral contraceptive pill. What should the pharmacist recommend for JM in order to avoid contracting meningitis?
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