Active substances: Ciprofloxacin
Ehrmann. Both forms can be found at the web site.
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Protein profiling is an emerging independent subspecialty of proteomics that is rapidly expanding and providing unprecedented insight into biological events.
Quantitative assessment of protein levels in hematologic malignancies seeks a comprehensive understanding of leukemiaassociated protein patterns for use in aiding diagnosis, follow-up treatment, and the prediction of clinical outcomes.
Many recently developed high-throughput proteomic methods can be applied to protein profiling.
Herein the importance of protein profiling, its exploitation in leukemia research, and its clinical usefulness in the treatment and diagnosis of various cancer types, and techniques for determining changes in protein profiling are reviewed.
Protein profiles in leukemia Introduction Proteins are abundant in all organisms and play key roles in most biological events as catalysts, transporters, and messengers. Thus, it is crucial to note that all research related to proteins increase our understanding of their levels, interactions, functions, modifications, regulations, and localization in cells.
Proteomics is a rapidly expanding discipline that aims to gain a comprehensive understanding of proteins.
The term proteomics, which is a combination of protein and genomics, is used to define the large-scale analysis of a complete set of proteins - the chief components of cells that are responsible for the most significant metabolic pathways in cells or tissues.
The goal underlying proteomics is not only to identify all proteins in a cell, but also to identify the correlation between the genetic sequence and three-dimensional 3 D protein structure. In other words, work in proteomics encompasses the investigation of proteinprotein interactions, the connection between the structure of proteins and their function, cellular processes and networks, and to improve protein separation and protein profiling techniques.
Protein profiling, an emerging independent subspecialty of proteomics, is poised to provide unprecedented insight into biological events. Quantitative evaluation of protein levels can be accomplished with protein profiling, which shows us unique expression patterns diseased vs.
The value of protein profiling is increasing daily and there are several reasons why it is of great importance, especially as a potential tool for the early diagnosis of leukemias and other diseases. One such reason is that it provides a much better understanding of an organism, as it is not always possible or sufficient for scientists to clarify some metabolic pathways, including mechanisms of diseases, exclusively by studying the genome.
Additionally, there are some difficulties associated with accurately indentifying genes solely by dealing with genomic data.
To overcome this problem, data provided from genomic studies should be supported with data obtained from the study of proteins.
Proteomics is often considered as the stage following genomics in the study of biological systems. Compared to genomics, proteomics is much Turk J Hematol.
This is because distinct genes are expressed in distinct cell types, and to identify even a basic group of proteins produced in a cell, one needs to have a comprehensive understanding of protein-related actions.
Until recently, such research was carried out using mRNA analysis via different methods, including microarray technology and serial analysis of gene expression SAGE. On the other hand, recent studies demonstrate that mRNA analysis cannot be correlated directly with protein levels, as mRNA is not always translated into proteins.
Moreover, the quantity of protein formed for a given quantity of mRNA depends on both the gene that it is transcribed from and the current physiological state of the cell.