Active substances: Hydroxyzine
We evaluated several drugs to determine the effectiveness of reducing PRV-induced pelvic pain. Referred hyperalgesia and tactile allodynia was tested using von Frey filaments applied to the abdomen.
Frequency of withdrawal responses to the application of von Frey filaments to the abdomen was tested using five individual fibers with forces of 0. Stimulation was confined to the lower abdominal area in the general vicinity of the bladder and care was taken to stimulate different areas within this region to avoid desensitization or "wind up" effects.
Three types of behaviors were considered as positive responses to filament stimulation: 1 sharp retraction of the abdomen; 2 immediate licking or scratching of the area of filament stimulation; or 3 jumping.
Results H 1 R antihistamine effects on PRV-induced pelvic pain Pain originating from a visceral organ is typically referred to a corresponding "dermatome" on the skin that shares common spinal cord innervation with the given visceral organ.
A role for histamine and histamine receptors in pain responses has been documented in both humans and animal models. To examine H 1 R as a therapeutic target for pelvic pain, we examined the effects of pharmacologic antagonists on the development of PRV-induced pain responses.
Table 2 Therapeutic modulation of PRV-associated pelvic pain. Full size table Figure 1 Antihistamines specific for H 1 receptor attenuate pelvic pain.
The symbol key shown in A applies to panels A-D. Full size image Antihistamines specific for H 2 R significantly attenuate PRV-induced pelvic pain To evaluate histamine 2 receptor as a therapeutic target for pelvic pain, we examined the effects of pharmacologic antagonists on the development of PRV-induced pain responses.
These data demonstrate that PRV-induced pelvic pain can be significantly attenuated by H 2 R antagonists. Figure 2 Antihistamines specific for H 2 receptor attenuate pelvic pain. Sixth St.
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