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  • Studies of the CNS effects of antihistamines are often conducted in healthy volunteers because the results can be extrapolated to patients with allergic disease.

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    Positron emission tomography PET represents a major breakthrough, providing a sensitive reference method for quantifying CNS penetration. Pooled analyses of clinical trial data have confirmed a close correlation between PET-determined H 1 RO and the incidence of sedation.

    Altogether, the non-sedating properties of antihistamines require full characterization according to subjective sleepiness recorded on scales such as the Stanford Sleepiness Scale; objective assessments of cognitive and psychomotor function e.

    Subjective sleepiness should be determined in large scale, double-blind, placebo-controlled studies, and assessments of cognitive function at least two tasks should also be performed in large study populations.

    No statistically significant differences should be observed between the test antihistamine and placebo.

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    Various methods of PET imaging with radiolabelled -doxepin have been used successfully for quantification of H 1 RO; for example, a simplified reference tissue model approach and Logan graphical analysis with reference tissue or arterial sampling.

    Bilastine is approved in several countries for the treatment of allergic rhinoconjunctivitis seasonal and perennial and urticaria. It is a non-sedating and long-acting antihistamine, with selective H 1-receptor affinity, and no affinity for other aminergic receptors.

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    In a comparative study with lorazepam on memory effects, patients who had taken online experienced vistaril effects like drowsiness, but recalled that they felt capable, attentive and able to continue with a memory test under these conditions.

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