Active substances: Hydroxyzine
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Evidence synthesis of seven RCTs favoured epidural anaesthesia for thoracotomy, suggesting the odds of having PPP three to 18 months following an epidural for thoracotomy were 0.
Simlarly, evidence synthesis of 18 RCTs favoured regional anaesthesia for the prevention of persistent pain three to 12 months after breast cancer surgery with an OR of 0.
Pooling data at three to 8 months after surgery from four RCTs favoured regional anaesthesia after caesarean section with an OR of 0. However, evidence synthesis of two RCTs also favoured the infusion of intravenous local anaesthetics for the prevention of PPP three to six months after breast cancer surgery with an OR of 0.
We did not synthesize evidence for the surgical subgroups of limb amputation, hernia repair, cardiac surgery and laparotomy. We could not pool evidence for adverse effects because the included studies did not examine them systematically, and reported them sparsely.
Clinical heterogeneity, attrition and sparse outcome data hampered evidence synthesis. High risk of bias from missing data and lack of blinding across a number of included studies reduced our confidence in the findings.
Thus results must be interpreted with caution. Our conclusions are considerably weakened by the small size and number of studies, by performance bias, null bias, attrition and missing data.
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It is also used together with other medications given for anesthesia. Atarax is also used to treat allergic skin reactions such as hives or contact dermatitis. Important information You should not use Atarax if you are allergic to hydroxyzine, or if you are pregnant.
Before you take Atarax, tell your doctor if you have a seizure disorder, liver disease, or kidney disease. Be careful if you drive or do anything that requires you to be alert. Stop using Atarax and call your doctor at once if you have a serious side effect such as tremors, confusion, seizures, or restless muscle movements in your eyes, tongue, jaw, or neck.
Drinking alcohol can increase certain side effects of hydroxyzine.