Active substances: Amoxicillin
Table 5 Antimicrobial susceptibility of S.
However, these breakpoints vary over time and due to differing guidelines. Hence, the importance of maintaining a database of raw MIC values rather than categorical reports from laboratories to track resistance trends.Most of us are indoctrinated.
CLSI, the most widely used guideline, has based preliminary breakpoints on MIC distributions, pharmacokinetic—pharmacodynamic PK—PD parameters and mechanisms of antimicrobial resistance.
These suggestions were later confirmed in clinical trials. Modern principles and methodologies are now utilized to evaluate the PK—PD of antimicrobials.
In this study, we have compared the susceptibility data calculated using both EUCAST and CLSI breakpoints for large numbers of respiratory pathogens collected during several national and international studies to discuss the implications, if any, for empiric therapy of patients to be treated for community-acquired respiratory infections.
Concerning S. Penicillin, however, remains the treatment of choice because of its proven efficacy and safety, and its narrow spectrum and low cost. To date no strain of penicillin-resistant S.
Macrolides are a suitable alternative for patients allergic to penicillin.
However, macrolides have often been incorrectly used as first-line agents, leading to high rates of macrolide resistance.
For the patient infected with an erythromycin-resistant strain of S. Using EUCAST breakpoints, the percentages of macrolides and clindamycin susceptible isolates were very similar to those obtained following CLSI criteria and no relevant discrepancies were observed.