Active substances: Isotretinoin
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The patient weight ranged from 50 to 110 kg mean: 65. Total clearance was achieved in 135 out of 140 patients treated with the use of this method 96.
The longest time of the therapy was 22 months, the shortest — 10 months. Within a 5-year observation period, recurrences were found in 11 7. Mean time from treatment completion to a relapse was 17.
Adverse effects during the therapy were mild and included: cheilitis 66.
Slightly elevated levels of liver enzymes and lipids in serum were found in 20 subjects.
The study was done on 50 patients 25 females, 25 males; a half of the group received the above treatment regimen while the other half was given isotretinoin locally only.
The patients were divided into 2 age groups: group I consisted of patients aged 12—20 years while group II — those aged 21—35 years.
After a 3-month therapy, an improvement was observed in 90. Four patients did not complete the therapy.
Within a 2-year observation period after the treatment, recurrences occurred in 3.
Rademaker et al. A randomized study with double-blind trial was carried out on 60 patients, aged 25—55 years.Address for correspondence: Jolanta D. Probenecid interferes with renal secretion of.
All patients underwent a check-up 10 weeks after completing the therapy 45 patients finished the study. The fastest significant reduction in skin lesions was observed within the first 4 weeks of the treatment group I. A systematic though less dynamic improvement was seen until the 32 nd week of the therapy mean number of skin lesions before the therapy — 11.
A similar, statistically significant reduction in skin lesions was found in group II, however, only in week 20. Isotretinoin 13-cis-retinoic acid, a first-generation retinoid, influences the basic pathogenic factors for acne: suppresses sebum production, demonstrates comedolytic activity, has direct and indirect anti-inflammatory activity, despite having no antibacterial properties, significantly reduces Propionibacterium acnes population.
The use of isotretinoin in Member States of the European Union, regulated by the Directive of the European Medicine Agency EMA, is approved for severe forms of acne, such as nodular or conglobate acne or acne at risk of scarring.
However, many groups of recognized experts, including the team appointed by the Polish Dermatological Society to develop consensus treatment for acne, recommend isotretinoin therapy also to patients with less severe acne.
The undeniable advantages of the intermittent therapy include: very good tolerability, easy management, and low cost. A reduction in sebum production, cheilitis reported by most patients confirm activity of even low doses of isotretinoin.
Drug accumulation the concentration of retinoid returns to the physiological level after 2 weeks explains the improvement of the lesions despite interruptions in the application of the drug.
Our results suggest that the proposed intermittent low-dose therapy with isotretinoin is preferred by the patients, which is proved by patients with recurrences being willing to repeat the therapy. Here are the top headlines everyday to keep you up to date on all the best films.
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