Active substances: Isotretinoin
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Dry skin, lips, nostrils and eyes Because isotretinoin reduces oil production in the skin, it can cause dry skin, dry mouth, chapped lips, dry nostrils and dry eyes. These effects can be uncomfortable.
Here are some tips to manage them, but if you have any questions, ask your doctor or pharmacist for advice. Skin: from the start of treatment, use a non-perfumed moisturizing cream.
Use non-soap cleansers, as these are less likely to irritate the skin, compared with a soap cleanser. Avoid beauty treatments such as chemical peels, dermabrasion and waxing during treatment, and for at least 6 months after stopping.
Ask your pharmacist to recommend a suitable eye lubricant also called artificial tears. Read more about eye lubricants. Increased sensitivity to the sun Isotretinoin can make you more sensitive to the sun and your skin is more likely to burn.
Avoid unnecessary sun exposure.
Treatment of acne scars is generally deferred until 12 months after completion of a course of isotretinoin.
Acne usually flares up 2—3 weeks into the treatment and is usually mild and tolerable.Wound healing is delayed inflammation and chapping of the lips cheilitis, redness of the skin erythema, rashes, peeling, eczema dermatitis, itching pruritus. Other common mucocutaneous side effects are expiry date, which is stated on strong inhibitors of the CYP450 1A2 isozyme such as fluvoxamine, may result of methotrexate-associated toxic reactions.
Occasionally this flare-up is severe, necessitating oral antiobiotics such as erythromycin.
Some dermatologists favour a few weeks of pre-treatment with oral antibiotics before commencing isotretinoin to reduce the chance of a severe flare. Isotretinoin use can rarely lead to a more severe form of acne, acne fulminans.
Teratogenicity Isotretinoin is a teratogen highly likely to cause birth defects if taken by women during pregnancy or even a short time before conception.
A few of the more common birth defects this drug can cause are hearing and visual impairment, missing or malformed earlobes, facial dysmorphism, and abnormalities in brain function. About 160 babies with birth defects were born.
After the FDA put the more strict iPLEDGE program in place for the companies marketing the drug in the US, in, 155 pregnancies occurred among 129,544 women of childbearing potential taking isotrentinoin 0.
Very rare effects include abnormal behaviour, psychosis, suicidal ideation, suicide attempts and suicide.
Beginning in 1983, isolated case reports emerged suggesting mood change, particularly depression, occurring during or soon after isotretinoin use. This therapy must only be used under the guidance of a skin specialist because of the possible risks.