Active substances: Isotretinoin
Hence, we recommend this low dose therapy for treatment of moderate to severe scar prone acne.
A large, prospective randomized comparative study is needed to establish the definitive response and tolerance of this protocol. Footnotes Conflict of Interest: None declared. Prevalence of facial acne vulgaris in late adolescence and in adults.
Br Med J. Oral isotretinoin is as effective as a combination of oral isotretinoin and topical anti-acne agents in nodulocystic acne. Indian J Dermatol Venereol Leprol. Roaccutane treatment guidelines: Results of an international survey.
Isotretinoin versus placebo in the treatment of cystic acne. A randomized double-blind study.
J Am Acad Dermatol. A review of the European Directive for prescribing systemic isotretinoin for acne vulgaris.
J Eur Acad Dermatol Venereol. Isotretinoin therapy for acne: Results of a multicenter dose-response study.Serious allergic reaction In rare cases, it's possible to have a serious allergic reaction anaphylaxis to isotretinoin capsules.
Brelsford M, Beute TC. The response to isotretinoin is variable. Dissecting cellulitis of the scalp also responds variably to oral isotretinoin, but a 4-month course should be tried.
There have to date been variations in the way treatment is started. The European Directive advocates a starting dose of 0.
Absorption of isotretinoin is markedly affected by the presence of fat and pharmacokinetic studies show that absorption can be doubled by taking isotretinoin with,, a meal compared with the fasting state.
The dose can then be adjusted according to clinical response and presence or absence of side effects. The range is usually 16—30 weeks, with a mean between 16 and 20 weeks with patients receiving 0.
Studies to derive a cumulative dose for maximum benefit and reduced relapse rate have confirmed that there is a definite effect of both dose and duration of therapy but that there is not a priori pharmacokinetic reason to support the concept of accumulation of drug or a cumulative dose effect.
Table 2 outlines poor prognostic factors. Eighty-five percent of patients who receive a dose of 0. It's very important that you do not get pregnant while you're taking isotretinoin capsules.
You'll be asked by your doctor to follow strict rules to prevent pregnancy during treatment and for 1 month afterwards. Read this card and the information leaflet that comes with your medicine before you start taking the capsules.
Do not breastfeed while you're using isotretinoin capsules.