Active substances: Isotretinoin
In only twenty patients, slight elevation of liver enzymes and serum lipids was detected.
Safety was assessed during the study by the reporting of adverse events.
The most common side-effects in our study were mild cheilitis in 93 patients 66.
The observed side-effects were mild, and only 6 patients discontinued study medication because of severe adverse events.
Isotretinoin can cause variant side-effects; mucocutaneous side-effects are the most common, experienced by virtually all patients. Epistaxis only seen in conventional group but in our study. Elevated liver function test results, and increase in serum lipid profiles was mild, and usually returned to normal within 6-8 weeks, despite continuation of treatment.
The present study showed that low dose 20 mg daily isotretiinoin represents a well-tolerated and efficient alternative to the standard 0. The only pitfall is it is longer than 10 months duration of treatment period.
The low frequency of adverse side-effects in this study, suggest that most side effects of the drug, are dose dependent; and the most serious side effects of the drug can be reduced significantly by using lower doses.
Hence, we recommend this low dose therapy for treatment of moderate to severe scar prone acne. A large, prospective randomized comparative study is needed to establish the definitive response and tolerance of this protocol.
Footnotes Conflict of Interest: None declared. Prevalence of facial acne vulgaris in late adolescence and in adults.
Br Med J. Oral isotretinoin is as effective as a combination of oral isotretinoin and topical anti-acne agents in nodulocystic acne. Conclusion: Modest doses of adjunctive LEV can improve clinical presentation in BPD patients with incomplete response to standard ther- apies.
LEV was well tolerated and safe. These observations raise questions about the nature of the relationship between the neurobiological mechanisms of BD and suicide, namely whether they are shared or independent.
Methods: We studied 539 subjects from 78 families of probands with major affective disorders, all responders to lithium prophylaxis.
ACox proportional hazard regres- sion model was used to assess the contribution of several independent variables to the risks of AD, BD, and suicidal behavior.
Conclusions: Suicidal behavior is distributed unevenly in families of probands with BD, aggregating in a subset of families. The predictive value of depressive symptoms for suicide has been extensively studied in chronic schizophrenia and affective psy- chosis.
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