Active substances: Isotretinoin
We chose these outcome measures for the sensitivity analysis because the blinding of outcome assessment can have a major influence on them. The sensitivity analysis changed the direction of the two clinical outcomes.
Of the three studies 13, 14, 15 evaluated for remaining inflammatory acne lesion counts, one study 15 was a company-sponsored study and reported greater efficacy in the doxycycline daily therapy group. In contrast, two studies 13, 14 that showed their blinding of outcome assessment clearly reported more favorable efficacy in the azithromycin pulse therapy group.
Similarly, of the six studies 10, 12, 13, 14, 15, 16 that evaluated the investigator's assessment of treatment, three studies 10, 12, 16 that did not show their blinding of outcome assessment clearly reported more favorable efficacy in the doxycycline daily therapy group.
The one company-sponsored study 15 showed more favorable efficacy in the doxycycline daily therapy group.
Sometimes, company-sponsored studies are significantly more likely to paint a rosy picture of the drug being evaluated than independent trials.
Two studies 12, 16 did not report any side effects. Both of them reported more favorable efficacy in the doxycycline daily therapy group and were among the previous three studies that showed high detection bias. In light of this, there could also be reporting bias.
Taken together, the high risk of blinding of outcome assessment of studies could have led to an overestimation of doxycycline efficacy in their assessment. Of all six studies, one study 16 was distinctively heterogeneous compared with the other five.
It reported the most favorable efficacy of doxycycline daily therapy among all six studies. However, the study did not report any adverse events and also did not describe its blinding of outcome assessment.
This could have created reporting bias and thus led to an overestimation of doxycycline efficacy.
Antibiotics are a well-known mainstream treatment for acne because of their anti-inflammatory and antimicrobial properties. Systemic antibiotics have been proven to reduce not only, inflammatory, but also non-inflammatory, lesions of acne.
Research has also shown that once P. Try to keep your showers shorter than 2 minutes, using lukewarm water rather than hot.
Do not use a sunlamp or sunbeds. If you wear contact lenses and these become uncomfortable, you might have to wear glasses instead while you're taking this medicine. How and when to take it It's important to take the capsules as instructed by your doctor.