Active substances: Isotretinoin
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Improvement of acne lesions generally started during the 6 th week, and was considered excellent at the end of treatment by all patients.
Marked clinical improvement in inflammation, flattening of papulopustular lesions, started 1 or 2 months after initiation of treatment.
Pustules tend to clear more rapidly than papules or nodules, and the lesions on the face, and upper arms, responded more quickly than trunk lesions.
There are different opinions about the dose of isotretinoin for treatment of acne.
The suggested standard dose is 0. Low dose isotretinoin to treat acne, has been tried previously. The higher values 96. Hermes et al.
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