Active substances: Isotretinoin
Panelists who have first hand experience with international intervention will share their insights. The present study showed that low dose 20 mg daily isotretiinoin represents a well-tolerated and efficient alternative to the standard 0.
The only pitfall is it is longer than 10 months duration of treatment period. The low frequency of adverse side-effects in this study, suggest that most side effects of the drug, are dose dependent; and the most serious side effects of the drug can be reduced significantly by using lower doses.
Hence, we recommend this low dose therapy for treatment of moderate to severe scar prone acne.
A large, prospective randomized comparative study is needed to establish the definitive response and tolerance of this protocol. Footnotes Conflict of Interest: None declared.Adam Mamelak. At the very least, you should.
Prevalence of facial acne vulgaris in late adolescence and in adults. Br Med J. Oral isotretinoin is as effective as a combination of oral isotretinoin and topical anti-acne agents in nodulocystic acne.
Indian J Dermatol Venereol Leprol. Roaccutane treatment guidelines: Results of an international survey. Isotretinoin versus placebo in the treatment of cystic acne. A randomized double-blind study.
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A review of the European Directive for prescribing systemic isotretinoin for acne vulgaris. J Eur Acad Dermatol Venereol. Isotretinoin therapy for acne: Results of a multicenter dose-response study. Brelsford M, Beute TC.
Preventing and managing the side effects of isotretinoin. Isotretinoin capsules are usually only used for people whose acne doesn't improve with other treatments. But there are other options for some people with severe acne, for example, treatments that use lasers, and other light devices and chemical peels.
Why is isotretinoin no longer available as a gel? Isotretinoin used to also come as a gel, known by the brand name Isotrex. In GSK stopped manufacturing Isotrex gel.
This medicine is no longer available in the UK. However there is a gel containing isotretinoin and erythromycin brand name Isotrexin. There are also other gels that contain tretinoin or adapalene. These work in a similar way to isotretinoin gel.
Ask your specialist or a pharmacist for advice about suitable alternatives and the best treatment for your condition. Will it affect my fertility?